As elevated GM-CSF levels can be seen in synovial fluid and blood from patients with inflammatory disorders. Assay Ready Cells targeting GM-CSF have been developed by Euro Diagnostica (Biomonitor) and are expected to be a useful tool in the drug development process for treatment of inflammatory and autoimmune diseases.
The iLite™ GM-CSF Assay Ready Cells express luciferase under the control of a GM-CSF responsive promoter. When stimulating the cells with GM-CSF the resulting luminescent signal is proportional to the functional activity of GM-CSF in the sample. The cells can therefore be utilized as a highly sensitive assay for quantification of GM-CSF functional activity, GM-CSF inhibitor activity or neutralizing antibodies against GM-CSF in test samples, including human serum.