Latest addition to Euro Diagnostica’s portfolio of iLite™ Assay Ready Cells within inflammation: iLite™ GM-CSF Assay Ready Cells!

November 3, 2016 - Company News, Product News
Anti-inflammatory drugs are commonly used to treat inflammation and autoimmune diseases, they help manage chronic pain, inflammation, and swelling. The growth factor GM-CSF (Granulocyte-macrophage colony stimulating factor) has shown to be a key player in inflammation and autoimmunity. The inhibition of GM-CSF is an attractive approach for the treatment of these diseases and has proven to have a much broader range of biological activities in both innate and adaptive immune responses.

As elevated GM-CSF levels can be seen in synovial fluid and blood from patients with inflammatory disorders. Assay Ready Cells targeting GM-CSF have been developed by Euro Diagnostica (Biomonitor) and are expected to be a useful tool in the drug development process for treatment of inflammatory and autoimmune diseases.

The  iLite™ GM-CSF Assay Ready Cells express luciferase under the control of a GM-CSF responsive promoter. When stimulating the cells with GM-CSF the resulting luminescent signal is proportional to the  functional activity of GM-CSF in the sample. The cells can therefore be utilized as a highly sensitive assay for quantification of GM-CSF functional activity, GM-CSF inhibitor activity or neutralizing antibodies against GM-CSF in test samples, including human serum.

To learn more about iLite™ GM-CSF Assay Ready Cells click here.



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