It is according to the authors a true problem and it is related to the use of RF in the diagnosis. The lack of specificity of RF in result in a very high frequency of RF positive HCV infected patients. The use of anti-CCP will with its much higher specificity increase the diagnostic accuracy significantly. The authors even suggest a renaming of RF to more reflecting that it is not really specific for rheumatoid arthritis.
Stratta P, Cristina Bozzola C, and Quaglia M: Rheumatoid factor: The end of the term as we know it? Comment on the editorial by Liao et al. Arthritis & Rheumatism 2012; 64: 320–321.