Alport's Syndrome kit WIESLAB®

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Patients with Alport syndrome have mutations in the gene for the alfa 5 chain of type IV collagen. This results in a lack of the alfa 5 (IV) chain from glomerular basement membrane (GBM) and the skin basement membrane as well as a lack of the alfa 3 (IV) chain from GBM. Analysis of kidney biopsies and skin biopsies for Alport syndrome can be tested for the presence or absence of the type IV collagen alpha-3, alpha-4 and alpha-5 chains (COL4A3, COL4A4, COL4A5).

Product code
ALP 105 RUO
Format
Immunohistochemical staining on Cryostat tissue or paraffin embedded tissue
Tests
200-400
Calculation
Qualitative
Antigen
Alpha 1, 3, 5 of Col IV
Availability
Research use only

Purpose of research product

Immunohistochemical staining kit for indirect detection of mutations in the gene for the alfa 5 chain of type IV collagen in Alport’s syndrome. The result shall not be used for clinical diagnosis or patient management.

Kit Components

200 µl Mouse monoclonal antibody to alfa 1 chain of type IV collagen (MAB 1)

200 µl Mouse monoclonal antibody to alfa 3 chain of type IV collagen (MAB 3)

100 µl Rat monoclonal antibody to alfa 5 chain of type IV collagen (MAB 5)

1 x 23 mL Glycine/urea solution