iLite® Diluent A

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Product code
6 mL
Detection system
Research use only

The iLite® Diluent A can be used in the anti-TNF-alpha drug concentration assay. It may be used for the dilution of test samples and for the preparation of calibrator and control samples.
Application Notes for the following assays are available:
Quantification of TNF-alpha blockers using iLite® TNF-alpha Assay Ready Cells (E-173-GB)

Tumor necrosis factor alpha (TNF-alpha) promotes inflammatory responses, which, in turn, contribute to the clinical problems associated with many inflammatory disorders, including rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis and refractory asthma. These diseases are sometimes treated with TNF-alpha inhibitors, including infliximab, adalimumab, etanercept, certolizumab pegol, or golimumab. Prolonged therapies with these TNF-alpha inhibitors may lead to development of neutralizing antibodies (NAbs), which may counteract the TNF-alpha antagonist activity of the drugs.

6 mL of iLite® Diluent A containing RPMI 1640 with 8% heat inactivated normal human serum (NHS).